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What is Aprovel?

Aprovel is a medicine that contains the active substance irbesartan. It is used in adults who have essential hypertension (high blood pressure). Aprovel is also used to treat kidney disease in adults with hypertension and type-2 diabetes.

How is Aprovel used?

Usual recommended dose of Aprovel is 150 mg once a day. If the blood pressure is not sufficiently controlled, the dose can be increased to 300 mg a day.

How does Aprovel work?

The active substance in Aprovel, irbesartan, is an ‘angiotensin-II-receptor antagonist’, that means it blocks the action of a hormone in the body called angiotensin II.

How has Aprovel been studied?

Aprovel was initially studied in 11 trials for its effects on theblood pressure. It was compared with placebo (a dummy treatment) in 712 patients and with other medicines for hypertension (atenolol, enalapril or amlodipine) in 823 patients.

What are the risks associated with Aprovel?

The most common side effect with Aprovel (seen in more than 1 patient in 10) is hyperkalaemia (high blood potassium levels).

Why has Aprovel been approved?

The CHMP decided that Aprovel’s benefits are greater than its risks and recommended that it be given marketing authorization.