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Valsartan-Hydrochlorothiazide

[ Generic Medicines for High Blood Pressure Treatment ]

Valsartan/Hydrochlorothiazide is a combination of two active ingredients. Valsartan is a triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. This medication blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland. It prevents AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium. It results in vasodilation, maximized excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.

Hydrochlorothiazide is a thiazide diuretic used to treat hypertension and edema. It appears to preferentially bind to and accumulate in red blood cells. This medicine is a diuretic indicated for the treatment of hypertension and congestive heart failure. It plays the role of a xenobiotic, an environmental contaminant, a diuretic, and an antihypertensive agent.

Class of Drugs –Antagonist of angiotensin + Diuretic

Molecular Formula – C24H29N5O3 + C7H8ClN3O4S2

Molecular Weight - 435.5 g/mol + 297.7 g/mol

Working: This active medication belongs to a group of drugs called angiotensin II receptor blockers. This active component Valsartan/Hydrochlorothiazide works by blocking the effect of angiotensin. This process relaxes the blood vessels more and allows the kidney to get rid of extra water and salt. It helps lower blood pressure.

Uses: Given medication is indicated for the treatment of high blood pressure and heart failure. It improves the chance of living longer after a heart attack. In people with heart failure, Valsartan/Hydrochlorothiazide may also lower the chance of having to go to the hospital for heart failure. It relaxes blood vessels so that blood can flow more easily. Decreasing high blood pressure that prevents strokes, heart attacks, and kidney problems.

Popular Brands and Dosages: This combination of two active ingredients in a popular brand medicine as mentioned below:

  • Diovan: 40 mg, 80 mg, and 160 mg

This combination of active ingredients is not recommended in people with diabetes.