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Telmisartan-Amlodipine Besylate

[ Generic Medicines for High Blood Pressure Treatment ]

Telmisartan / Amlodipine Besylate is a combination of two active ingredients. Telmisartan is a non-peptide angiotensin II receptor antagonist that has antihypertensive properties. This medication antagonizes angiotensin II binding to the AT1 subtype receptor, present in vascular smooth muscle and adrenal gland. It leads to vasodilation and inhibits angiotensin II-mediated aldosterone production that also decreases sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure.

Amlodipine Besylate component shows antihypertensive and antianginal effects. It acts by inhibiting the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells. It is for preventing vascular and myocardial contraction. This active component may also modulate multi-drug resistance activity via inhibition of the p-glycoprotein efflux pump.

Class of Drugs – Calcium channel blockers + An angiotensin receptor blocker

Molecular Formula – C33H30N4O2 + C26H31ClN2O8S

Molecular Weight - 297.7 g/mol + 567.1 g/mol

Working: This mentioned medicine Telmisartan / Amlodipine Besylate contains two components. One of them belongs to a group of drugs known as calcium channel blockers. This drug works by relaxing the muscles of the heart and blood vessels. Another component is in a group of drugs known as angiotensin II receptor antagonists that keeps blood vessels from narrowing, which reduces blood pressure and improves blood flow.

Uses: This active medication is approved for the treatment of high blood pressure. Reducing high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication works uniquely to relax the blood vessels so that blood can flow more easily.

Telmisartan / Amlodipine Besylate indicated together when one drug is not controlling the blood pressure.

Popular Brands and Dosages: This combination of two active ingredients used in a popular brand medicine as given below:

  • Twynsta: 5 mg + 40 mg and 5 mg + 80 mg

In case of low blood pressure while treating with this medicine. Seek medical attention if you experience vomiting or diarrhea, or sweating more than usual.