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Isosorbide Dinitrate

[ Generic Medicines for High Blood Pressure Treatment ]

Wyeth Isordil

Isosorbide Dinitrate is an organic nitrate that shows vasodilator activity. This ingredient relaxes the vascular smooth muscle by the production of the free radical nitric oxide. It is identical to the endothelium-derived relaxing factor. This free radical of NO activates guanylyl cyclase so as to increase the synthesis of cGMP within a muscle. It results in the relaxation of peripheral arteries and veins. It also relaxes coronary arteries to increase blood circulation through the ischemic area. This active component is a nitrate vasodilator available as a conventional tablet form.

Class of Drugs – Nitrates

Molecular Formula – C6H8N2O8

Molecular Weight - 236.14 g/mol

Working: Given medication belongs to the group of medicines called nitrates. Isosorbide Dinitrate relaxes the blood vessels and increases the supply of blood and oxygen to the heart while decreasing its workload. It can also prevent angina attacks from occurring.

Uses: This nitrate medication dilates or widens blood vessels to make it easier for blood to flow through vessels. It becomes easy for the heart to pump. Isosorbide dinitrate is indicated for the treatment or prevention of attacks of chest pain i.e. angina.

Popular Brands and Dosages: This mentioned active ingredient is used in a popular brand medicine as given below:

  • Isordil: 5 mg and 10 mg

Medical history of anemia, low blood pressure, loss of too much body water (dehydration), other heart problems should be discussed with the doctor before consuming this medicine. A pregnant or breastfeeding woman should avoid this medicine, it may harm the nursing baby or fetus.