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Amlodipine Besylate / Atorvastatin Calcium

[ Generic Medicines for High Blood Pressure Treatment ]

Pfizer Caduet

Amlodipine Besylate / Atorvastatin Calcium is a combination of two active ingredients, a synthetic dihydropyridine with antihypertensive and antianginal effects. This medicine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells so as to prevent vascular and myocardial contraction. This leads to a dilatation of the main coronary and systemic arteries, reduced myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance activity through inhibition of the p-glycoprotein efflux pump.

Class of Drugs – Antihypertensive drug

Molecular Formula – C26H31ClN2O8S + C66H68CaF2N4O10

Molecular Weight - 567.1 g/mol + 1155.3 g/mol

Working: This given combination of two medicines is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. Amlodipine Besylate / Atorvastatin Calcium is an effective solution for the given condition.

Uses: In the medication, amlodipine is a calcium channel blocker and is indicated to treat high blood pressure or prevent chest pain, works by relaxing the blood vessels so that blood can flow more easily and the heart does not need to work so hard. Decreasing high blood pressure helps prevent strokes, heart attacks, and kidney problems. Preventing chest pain can help improve the ability to exercise.

Amlodipine Besylate / Atorvastatin Calcium is indicated along with a proper diet to help lower bad cholesterol and fats and raise good cholesterol in the blood. This drug belongs to a group of drugs known as statins. It reduces the amount of cholesterol made by the liver. This decreases the risk of heart disease and helps prevent strokes and heart attacks.

Popular Brands and Dosages: This combination of medications is used as the active ingredient in a popular brand medicine as given below:

  • Caduet: 5 mg + 10 mg

This drug must be continued even if you feel well. Most people with high blood pressure or high cholesterol/triglycerides do not feel sick.