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Entacapone

[ Generic Medicines for Epilepsy Treatment ]

Novartis Comtan

Entacapone is a nitro catechol compound with a property of anti-parkinsonian. It is a selective and reversible inhibitor of catechol-O-methyltransferase that catalyzes the transfer of the methyl group to the phenolic group of substrates that contain a catechol structure. This component used to prevent the metabolism and inactivation of adjunct drugs so as to increase the bioavailability of these compounds by providing their passage across the blood-brain barrier. It is available in conventional tablet form.

Class of Drugs – COMT inhibitors

Molecular Formula – C14H15N3O5

Molecular Weight - 305.29 g/mol

Working: Given medicine is indicated for the treatment of Parkinson's disease. This ingredient belongs to a class of drugs known as COMT inhibitors. This active component Entacapone blocks a certain natural substance that breaks down the levodopa in the body. Due to this effect, levodopa is allowed to last longer in the system so that it doesn't wear off before the next dose.

Uses: This mentioned medication is used with other medications like levodopa or carbidopa to treat Parkinson's disease. Mainly Entacapone is used to block a certain natural substance such as COMT enzyme that breaks down the levodopa in the body. It acts to retain the given drug dose of levodopa to last longer in the system up to the next dose.

Popular Brands and Dosages: This COMT inhibitor component is used in popular brand medicines as mentioned below:

  • Comtan: 200 mg
  • Stalevo: 200 mg
  • Prolopa: 200 mg
  • Sinemet: 200 mg

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and confusion.