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Carbidopa-Levodopa

[ Generic Medicines for Epilepsy Treatment ]

Carbidopa / Levodopa is a combination of two active ingredients for the treatment of Parkinson’s disease. Carbidopa component is a propanoic acid in which the hydrogens alpha- to the carboxyl group. This active component is a dopa decarboxylase inhibitor that prevents the conversion of levodopa to dopamine. It plays the role of an EC aromatic-L-amino-acid decarboxylase inhibitor, an antiparkinson drug, and a dopaminergic agent.

Levodopa acts as an aromatic amino acid decarboxylation inhibitor. The ingredient is used in combination with carbidopa, which is an inhibitor of L-amino acid decarboxylase.

Class of Drugs – A dopa decarboxylase inhibitor and aromatic amino acid decarboxylation inhibitor

Molecular Formula – C10H14N2O4 + C9H11NO4

Molecular Weight - 226.23 g/mol + 197.19 g/mol

Working: One of the ingredients Levodopa changes into dopamine in the brain that helps to control movement. Carbidopa prevents the breakdown of levodopa in the bloodstream so more levodopa can enter the brain. It reduces some of the levodopa's side effects such as nausea and vomiting. This combination may be used alone or with other drugs for Parkinson's disease.

Uses: The combination of Carbidopa / Levodopa is used to treat the symptoms of Parkinson's disease and other symptoms that may develop after encephalitis or injury to the nervous system caused by carbon monoxide poisoning or manganese poisoning. The medicine helps to relieve symptoms like tremors, stiffness, and slowness of movement.

Popular Brands and Dosages: The effective combination of active ingredients Carbidopa / Levodopa is used in popular brand medicine as mentioned below:

  • Sinemet: 100 mg+ 10 mg and 250 mg + 25 mg

Consult the doctor before consuming this medicine, do not go against the prescription by the doctor.