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Olanzapine

Olanzapine is a thienobenzodiazepine that shows antipsychotic, antinausea, and antiemetic activities. This medication is a selective monoaminergic antagonist that binds with high-affinity binding to the receptors such as serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic. These receptors bind weakly to gamma-aminobutyric acid type A and beta-adrenergic receptors.

This agent appears to the blockade of 5-HT2 and 5-HT3 receptors for serotonin antipsychotic activity is through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics. It helps to minimize extrapyramidal symptoms.

Class of Drugs – A selective monoaminergic antagonist

Molecular Formula – C17H20N4S

Molecular Weight - 312.4 g/mol

Working: The exact mechanism of action is not known. Olanzapine is believed that it may help to regulate the number of certain chemicals like dopamine and serotonin in the brain to help control the mood.

Uses: The mentioned medication Olanzapine is indicated for the treatment of certain mental/mood conditions such as schizophrenia, bipolar disorder. It is used in combination with other drugs to treat depression. It acts by reducing hallucinations and help to think more clearly and positively about oneself, feel less agitated, and take a more active part in everyday life.

This drug belongs to a group of drugs called atypical antipsychotics that works by restoring the balance of certain natural substances in the brain.

Popular Brands and Dosages: This drug is available for oral consumption and in dosages as given below:

  • Zyprexa: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg
  • Zyprexa Zydis: 5 mg, 10 mg, and 15 mg

It is not recommended to consume alcoholic beverages while treating with this medicine.