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Amgen Inc Corlanor

  • 5mg
  • Availability: In Stock

Amgen Inc Corlanor
  • 7.5mg
  • Availability: In Stock

Corlanor is an effective medication used in the treatment of heart failure. It is composed of active ingredient Ivabradine, which is a calcium channel blocker. One of the reputed pharmaceutical companies, Amgen Inc has been manufacturing this medicine. It is composed of the conventional tablet form and available in dosages as 5 mg and 7.5 mg.

Manufacturer: Amgen Inc

Active Ingredient: The main active component of the medicine is Ivabradine, which is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated channel blocker, with negative chronotropic activity. This component binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial node. This inhibits the If pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity, and slows diastolic depolarization. This lowers heart rate, reduces myocardial oxygen demand and allows more time for blood to flow to the myocardium without affecting cardiac contractility.

Indications: Ivabradine composed medication is used to treat heart failure. It is used by adults to help prevent the heart failure from getting worse and needing treatment in a hospital. Corlanor is also used by children who have heart failure due to an enlarged heart. Heart failure is a condition where your heart does not pump blood as well as it should. This medicine works by making your heart beat more slowly.

Action Mechanism: This effective medicine blocks the hyperpolarization-activated cyclic nucleotide-gated channel responsible for the cardiac pacemaker ‘funny’ current, which regulates heart rate. The cardiac effects were most pronounced in the sinoatrial node, but a prolongation of the AH interval has occurred on the surface ECG, as has PR interval prolongation. There was no effect on ventricular repolarization and no effects on myocardial contractility.

Dosages: This Corlanor medicine is available for oral consumption and in dosage as mentioned below:

  • 5 mg: This medicine shall be consumed with food as directed by the doctor, usually twice a day
  • 7.5 mg: It is advisable to consume twice a day exactly as prescribed by the doctor

Note: Avoid eating grapefruit or drinking grapefruit juice while using this mentioned medication unless the doctor advised you to do so.


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- Amgen Inc Corlanor