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Regorafenib

[ Generic Medicines for Cancer Treatment ]

Regorafenib is a medicinal drug with antiangiogenic and antineoplastic activities. It acts by binding to and inhibiting vascular endothelial growth factor receptors 2 and 3. It may lead to the inhibition of tumor angiogenesis and tumor cell proliferation. VEGFRs are receptor tyrosine kinases that vital role in tumor angiogenesis; the receptor tyrosine kinases RET, KIT, and PDGFR. The serine/threonine-specific Raf kinase is in tumor cell signaling. This multi-kinase inhibitor drug is indicated in the therapy of refractory metastatic colorectal cancer, hepatocellular carcinoma and gastrointestinal stromal tumor.

Class of Drugs – Kinase inhibitor drugs

Molecular Formula – C21H15ClF4N4O3

Molecular Weight - 482.8 g/mol

Working: This mentioned active ingredient is a type of targeted cancer drug called a cancer growth blocker. It is also known as kinase inhibitor drug works in two ways. Regorafenib restricts signals that tell cancer cells to grow and also stops the cancer cells from forming new blood vessels, which they need to be able to grow.

Uses: This medication is used as the main active component in drugs used to treat cancer of the colon and rectum. Regorafenib composed drug is also indicated to treat liver cancer and a certain cancer of the digestive system or gastrointestinal stromal tumor. This drug slower or stops the growth of cancer cells.

Popular Brands and Dosages: It is available for oral consumption in a conventional tablet form is a popular brand as given below:

  • Stivarga: 40 mg

Do not eat grapefruit or drink grapefruit juice while treating with this drug; it can increase the chance of side effects.