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Megestrol Acetate

[ Generic Medicines for Cancer Treatment ]

Megestrol Acetate is a synthetic derivative of the naturally occurring female sex hormone progesterone that shows potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, this active ingredient binds to and activates nuclear progesterone receptors in the reproductive system. It causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes the expression of target genes. This results in an alteration in protein synthesis, which modulates cell growth of reproductive tissues. This component also blocks luteinizing hormone release from the pituitary gland, so as to lead to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Without the stimulation of LH, estrogen hormone release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells.

Class of Drugs – Progesterone Hormone

Molecular Formula – C24H32O4

Molecular Weight - 384.5 g/mol

Working: The condition of cancers needs hormones to grow. Megestrol Acetate progesterone is similar to the female sex hormone progesterone. This medication works by changing the hormone balance in the body, which may stop cancer growth. The component can also act directly on cancer cells so that they cannot grow.

Uses: This mentioned medication is indicated to treat cancer of the breast or uterus. Megestrol Acetate is similar to a natural substance made by the body called progesterone.

Popular Brands and Dosages: This cancer-treating medicine is approved as the main active component in a popular brand medicine as mentioned below:

  • Megace: 40 mg and 160 mg

This medication shall be consumed as advised by the doctor. Do not go against the prescription by the doctor.