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Erlotinib Hydrochloride

[ Generic Medicines for Cancer Treatment ]

Erlotinib Hydrochloride is a medicinal drug available in oral conventional table form. It is the hydrochloride salt of a quinazoline derivative with antineoplastic properties. It acts by binding to the intracellular catalytic domain of epidermal growth factor receptor tyrosine kinase so as to inhibit the EGFR phosphorylation. It also blocks the signal transduction events and tumorigenic effects and used in the treatment of Non-small cell lung cancer.

Class of Drugs – A tyrosine kinase inhibitor

Molecular Formula – C22H24ClN3O4

Molecular Weight - 429.9 g/mol

Working: This given medicine is a type of cancer treatment drug called a tyrosine kinase inhibitor (TKI). The drug Erlotinib Hydrochloride works by blocking particular proteins on cancer cells that encourage cancer to grow. It blocks proteins called epidermal growth factor receptors. The type of cancers that have these receptors are called EGFR positive.

Uses: This conventional tablet medication Erlotinib Hydrochloride is indicated for the treatment of Non-small cell lung cancer. It is also used in the treatment of people with metastatic non-small cell lung cancer whose tumors have epidermal growth factor receptor exon. It is used as the test receiving first-line, maintenance, or second or greater line treatment after progression following at least one prior chemotherapy regimen. It can be useful with gemcitabine in the first-line treatment of people with locally advanced, unresectable or metastatic pancreatic cancer.

Popular Brands and Dosages: This tyrosine kinase inhibitor cancer drug can be used in popular brand medicines as mentioned below:

  • Tarceva: 100 mg and 150 mg      
  • Cytoxan: 100 mg and 150 mg
  • Vepesid: 100 mg and 150 mg
  • Rheumatrex: 100 mg and 150 mg

Direct sunlight may worsen any skin reactions that may occur while consuming this medicine. Limit the time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.